There will be no trains running between Bolton and Wigan for 10 days due to electrification works.
Electrification works, part of a £100m investment scheme, began on August 31 and continues until September 9.
Engineers from Network Rail are set to install overhead line equipment and improve signalling between Wigan North Western station and Lostock junction in Bolton.
The electrification of the railway is designed to accommodate Northern’s longer, electric trains that will produce less noise and be more environmentally friendly.
However, to safely conduct the work, there will be no trains running between Wigan and Bolton during the 10-day period.
Network Rail will provide replacement buses between Wigan North Western and Manchester Victoria, including stops at Hindley, Atherton, Daisy Hill, and Westhoughton.
Rail replacement buses will also be operated on this line on September 14, 22, 27, 28, and October 6, 12, 20, 27.
Sarah Bull, sponsor at Network Rail, said: "This 10-day rail closure is a major milestone in our work to electrify the line between Wigan and Bolton.
"We’ll be installing overhead equipment and improving signalling, readying the route for electric trains when they are introduced. I’d like to thank passengers for their continued patience during this project."
Craig Harrop, regional director for Northern, said: "I’d like to thank customers for their patience while this infrastructure improvement work takes place.
"We will have a fleet of rail replacement buses to get people where they want to be between Wigan North Western, Westhoughton, Daisy Hill, Ince and Lostock – but journey times are likely to be longer and so customers should plan accordingly."
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